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pentobarbital decreases levels of toremifene by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. CYP3A4 inducers improve amount of toremifene metabolism, decreasing the steady-condition concentration in serum.pentobarbital will reduce the extent or effect of oxybutynin by impacting hepatic/intestinal enzyme CYP3A4 metabolis